Assay Detail
Functional
CHEMBL5223375
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Inhibition of PMA-induced oxidative burst in human monocytes preincubated for 1 hr followed by PMA stimulation and measured after 30 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Monocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of vortioxetine derivatives as new COX-1/2 inhibitors in human monocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.59 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5280103 | — | — | 1 | 9.46 |
| CHEMBL5282171 | — | — | 1 | 8.57 |
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 8.54 |
| CHEMBL5274467 | — | — | 1 | 8.20 |
| CHEMBL5276877 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5280103 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL5282171 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL2104993 | VORTIOXETINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5274467 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5276877 | — | IC50 | = | 6.5 | nM | 8.19 |