Assay Detail
Functional
CHEMBL1000658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced TNFalpha production in human whole blood
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.40 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL527026 | — | — | 1 | 6.52 |
| CHEMBL501709 | — | — | 1 | 6.40 |
| CHEMBL495617 | — | — | 1 | 6.05 |
| CHEMBL523059 | — | — | 1 | 5.96 |
| CHEMBL498070 | — | — | 1 | 5.55 |
| CHEMBL524069 | — | — | 1 | 5.51 |
| CHEMBL220037 | — | — | 1 | 5.48 |
| CHEMBL524638 | — | — | 1 | 5.41 |
| CHEMBL498028 | — | — | 1 | 5.41 |
| CHEMBL498029 | — | — | 1 | 5.39 |
| CHEMBL230232 | — | — | 1 | 5.38 |
| CHEMBL495585 | — | — | 1 | 5.36 |
| CHEMBL497228 | — | — | 1 | 5.27 |
| CHEMBL499853 | — | — | 1 | 5.26 |
| CHEMBL498222 | — | — | 1 | 5.26 |
| CHEMBL496594 | — | — | 1 | 5.24 |
| CHEMBL497883 | — | — | 1 | 5.23 |
| CHEMBL230761 | — | — | 1 | 5.20 |
| CHEMBL197538 | — | — | 1 | 5.17 |
| CHEMBL496388 | — | — | 1 | 5.16 |
| CHEMBL496595 | — | — | 1 | 5.15 |
| CHEMBL498071 | — | — | 1 | 5.05 |
| CHEMBL483685 | — | — | 1 | 5.00 |
| CHEMBL483484 | — | — | 1 | 4.89 |
| CHEMBL482864 | — | — | 1 | 4.72 |
| CHEMBL482863 | — | — | 1 | - |
| CHEMBL498072 | — | — | 1 | - |
| CHEMBL495867 | — | — | 1 | - |
| CHEMBL495866 | — | — | 1 | - |
| CHEMBL495584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL527026 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL501709 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL495617 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL523059 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL498070 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL524069 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL220037 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL524638 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL498028 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL498029 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL230232 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL495585 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL497228 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL499853 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL498222 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL496594 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL497883 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL230761 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL197538 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL496388 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL496595 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL498071 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL483685 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL483484 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL482864 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL482863 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL498072 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL495867 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL495866 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL495584 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL526840 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL496591 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL496590 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL522217 | — | IC50 | - | — | - |