Assay Detail
Functional
CHEMBL1000707
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Cytotoxicity against human KB3-1 cells by MTT method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.59 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309355 | — | — | 1 | 8.30 |
| CHEMBL72772 | — | — | 1 | 7.58 |
| CHEMBL528538 | — | — | 1 | 7.44 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.40 |
| CHEMBL487129 | — | — | 1 | 7.30 |
| CHEMBL486928 | — | — | 1 | 6.92 |
| CHEMBL309352 | — | — | 1 | 6.89 |
| CHEMBL488371 | — | — | 1 | 6.75 |
| CHEMBL72223 | — | — | 1 | 6.64 |
| CHEMBL483808 | — | — | 1 | 6.51 |
| CHEMBL73950 | — | — | 1 | 6.40 |
| CHEMBL487130 | — | — | 1 | 6.05 |
| CHEMBL488370 | — | — | 1 | 5.82 |
| CHEMBL486929 | — | — | 1 | 5.77 |
| CHEMBL485170 | — | — | 1 | 5.52 |
| CHEMBL306476 | — | — | 1 | 5.50 |
| CHEMBL484993 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309355 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL72772 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL528538 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL487129 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL486928 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL309352 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL488371 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL72223 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL483808 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL73950 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL487130 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL488370 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL486929 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL485170 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL306476 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL484993 | — | IC50 | = | 5800.0 | nM | 5.24 |