Assay Detail
Functional
CHEMBL1000781
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Cytotoxicity against human HCT116 cells after 4 days
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from thai marine sponge Xestospongia species pretreated with potassium cyanide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.70 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450755 | — | — | 1 | 8.72 |
| CHEMBL448327 | — | — | 1 | 8.52 |
| CHEMBL510507 | RENIERAMYCIN N | — | 1 | 8.25 |
| CHEMBL451147 | RENIERAMYCIN M | — | 1 | 8.10 |
| CHEMBL468488 | RENIERAMYCIN S | — | 1 | 7.82 |
| CHEMBL454372 | RENIERAMYCIN R | — | 1 | 7.64 |
| CHEMBL503821 | RENIERAMYCIN O | — | 1 | 7.55 |
| CHEMBL450708 | RENIERAMYCIN Q | — | 1 | 7.23 |
| CHEMBL449646 | — | — | 1 | 6.92 |
| CHEMBL500334 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450755 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL448327 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL510507 | RENIERAMYCIN N | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL451147 | RENIERAMYCIN M | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL468488 | RENIERAMYCIN S | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL454372 | RENIERAMYCIN R | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL503821 | RENIERAMYCIN O | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL450708 | RENIERAMYCIN Q | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL449646 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL500334 | — | IC50 | = | 630.0 | nM | 6.20 |