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Assay Detail

CHEMBL1000847

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of A-seco derivatives of betulinic acid with cytotoxic activity.
Urban M, Sarek J, Klinot J, Korinkova G, Hajduch M.
J Nat Prod (2004) 67 : 1100 -1105
PubMed 15270560 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 4.77 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL517089 1 5.40
CHEMBL481268 1 5.30
CHEMBL446020 1 5.22
CHEMBL519569 1 5.16
CHEMBL508907 1 4.80
CHEMBL431525 BETUNOLIC ACID 1 4.77
CHEMBL487011 1 4.70
CHEMBL505945 1 4.70
CHEMBL444653 1 4.66
CHEMBL520584 1 4.64
CHEMBL269277 BETULINIC ACID 1.0 1 4.57
CHEMBL450346 1 4.04
CHEMBL519610 1 4.02
CHEMBL481463 1 -
CHEMBL480883 1 -
CHEMBL376266 METHYL BETULONATE 1 -
CHEMBL487010 1 -
CHEMBL506061 1 -
CHEMBL507945 1 -
CHEMBL312687 1 -
CHEMBL450229 1 -
CHEMBL295602 METHYL BETULINATE 1 -
CHEMBL487205 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL517089 IC50 = 4000.0 nM 5.40
CHEMBL481268 IC50 = 5000.0 nM 5.30
CHEMBL446020 IC50 = 6000.0 nM 5.22
CHEMBL519569 IC50 = 7000.0 nM 5.16
CHEMBL508907 IC50 = 16000.0 nM 4.80
CHEMBL431525 BETUNOLIC ACID IC50 = 17000.0 nM 4.77
CHEMBL487011 IC50 = 20000.0 nM 4.70
CHEMBL505945 IC50 = 20000.0 nM 4.70
CHEMBL444653 IC50 = 22000.0 nM 4.66
CHEMBL520584 IC50 = 23000.0 nM 4.64
CHEMBL269277 BETULINIC ACID IC50 = 27000.0 nM 4.57
CHEMBL450346 IC50 = 91000.0 nM 4.04
CHEMBL519610 IC50 = 96000.0 nM 4.02
CHEMBL481463 IC50 = 250000.0 nM -
CHEMBL480883 IC50 = 250000.0 nM -
CHEMBL376266 METHYL BETULONATE IC50 = 250000.0 nM -
CHEMBL487010 IC50 = 113000.0 nM -
CHEMBL506061 IC50 = 240000.0 nM -
CHEMBL507945 IC50 = 250000.0 nM -
CHEMBL312687 IC50 = 200000.0 nM -
CHEMBL450229 IC50 = 250000.0 nM -
CHEMBL295602 METHYL BETULINATE IC50 = 150000.0 nM -
CHEMBL487205 IC50 = 101000.0 nM -