Assay Detail
Functional
CHEMBL1000906
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Cytotoxicity against human CEM cells after 96 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.86 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331627 | GLIOTOXIN | — | 1 | 6.82 |
| CHEMBL470243 | ASPIROCHLORINE | — | 1 | 6.24 |
| CHEMBL512142 | TETRATHIOASPIROCHLORINE | — | 1 | 5.38 |
| CHEMBL562 | GRISEOFULVIN | 4.0 | 1 | 5.00 |
| CHEMBL469410 | — | — | 1 | - |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331627 | GLIOTOXIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL470243 | ASPIROCHLORINE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL512142 | TETRATHIOASPIROCHLORINE | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL562 | GRISEOFULVIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL469410 | — | IC50 | > | 31000.0 | nM | - |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 160000.0 | nM | - |