Assay Detail
Functional
CHEMBL1001375
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Antiviral activity against HCV assessed as inhibition of viral RNA replication in Huh7 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.66 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237643 | — | — | 1 | 5.21 |
| CHEMBL477159 | — | — | 1 | 4.82 |
| CHEMBL235479 | — | — | 1 | 4.75 |
| CHEMBL516570 | — | — | 1 | 4.48 |
| CHEMBL512645 | — | — | 1 | 4.39 |
| CHEMBL244379 | — | — | 1 | 4.33 |
| CHEMBL469236 | — | — | 1 | - |
| CHEMBL468364 | — | — | 1 | - |
| CHEMBL477160 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237643 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL477159 | — | EC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL235479 | — | EC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL516570 | — | EC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL512645 | — | EC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL244379 | — | EC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL469236 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL468364 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL477160 | — | EC50 | > | 200000.0 | nM | - |