Assay Detail

CHEMBL1001650

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Functional

Antitumor activity against human MDA-N cells

ChEMBL ↗

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Target

MDA-N (CHEMBL614078) ↗

Open DB target context

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MDA-N (CHEMBL614078) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MDA-N

CHEMBL614078

Anchored from Assay target.

Protein identity MDA-N

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MDA-N
Confidence	1 — Organism
Curated By	Autocuration

Target

MDA-N (CHEMBL614078) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources.

Segraves NL, Robinson SJ, Garcia D, Said SA, Fu X, Schmitz FJ, Pietraszkiewicz H, Valeriote FA, Crews P.
J Nat Prod (2004) 67 : 783 -792
PubMed 15165138 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.25	6.25

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL258765	FASCAPLYSIN CHLORIDE	—	1	6.25
CHEMBL446125	FASCAPLYSIN A	—	1	6.24

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL258765	FASCAPLYSIN CHLORIDE	IC50	=	560.0	nM	6.25
CHEMBL446125	FASCAPLYSIN A	IC50	=	580.0	nM	6.24