Assay Detail
Binding
CHEMBL1002018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK4 by radioactive glutathione plate-binding assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.96 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526110 | — | — | 1 | 9.52 |
| CHEMBL495696 | GW778894X | — | 1 | 8.40 |
| CHEMBL468963 | GW779439X | — | 1 | 8.22 |
| CHEMBL495751 | — | — | 1 | 8.10 |
| CHEMBL188938 | — | — | 1 | 8.10 |
| CHEMBL495545 | — | — | 1 | 7.92 |
| CHEMBL513354 | — | — | 1 | 7.92 |
| CHEMBL359554 | — | — | 1 | 7.92 |
| CHEMBL497564 | — | — | 1 | 7.80 |
| CHEMBL496360 | — | — | 1 | 7.60 |
| CHEMBL359794 | — | — | 1 | 7.60 |
| CHEMBL522718 | — | — | 1 | 7.58 |
| CHEMBL521871 | — | — | 1 | 7.42 |
| CHEMBL496162 | — | — | 1 | 7.35 |
| CHEMBL524086 | — | — | 1 | 7.30 |
| CHEMBL525194 | — | — | 1 | 7.10 |
| CHEMBL523735 | — | — | 1 | 6.80 |
| CHEMBL496778 | — | — | 1 | 6.80 |
| CHEMBL496779 | — | — | 1 | 6.70 |
| CHEMBL495570 | — | — | 1 | 6.60 |
| CHEMBL503212 | — | — | 1 | 6.60 |
| CHEMBL495771 | GW708336X | — | 1 | 6.40 |
| CHEMBL497196 | — | — | 1 | 6.30 |
| CHEMBL524059 | — | — | 1 | 6.10 |
| CHEMBL498625 | — | — | 1 | 6.10 |
| CHEMBL496575 | — | — | 1 | 6.10 |
| CHEMBL513330 | GW781673X | — | 1 | 6.00 |
| CHEMBL446024 | GW683003X | — | 1 | 6.00 |
| CHEMBL497398 | — | — | 1 | 5.89 |
| CHEMBL445757 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526110 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL495696 | GW778894X | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL468963 | GW779439X | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL495751 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL188938 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL495545 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL513354 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL359554 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL497564 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL496360 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL359794 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL522718 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL521871 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL496162 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL524086 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL525194 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL496778 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL523735 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL496779 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL495570 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL503212 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL495771 | GW708336X | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL497196 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL524059 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL498625 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL496575 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL513330 | GW781673X | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL446024 | GW683003X | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL497398 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL445757 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL359963 | GW805758X | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL523747 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL524057 | GW683768X | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL524901 | GW683109X | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL495544 | — | IC50 | > | 40000.0 | nM | - |