Compound Detail
CHEMBL524057
GW683768X Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL524057 |
| Name | GW683768X |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RPRZAINAFJBVOV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
280.3
MW (Da)
2.32
ALogP
6
HBA
1
HBD
68.0
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 4 CHEMBL331 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 4 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of CDK4 by radioactive glutathione plate-binding assay | 18835709 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of VEGFR2 by HTRF assay | 18835709 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| - | 10.6019/CHEMBL2007661 | Serine/threonine-protein kinase TBK1 | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Srms | 2 |
| - | 10.6019/CHEMBL1961873 | Protein-tyrosine kinase 2-beta | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase FRK | 2 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor beta | 2 |
| - | 10.6019/CHEMBL1961873 | Muscle, skeletal receptor tyrosine-protein kinase | 2 |
| - | 10.6019/CHEMBL1961873 | Hepatocyte growth factor receptor | 2 |
| - | 10.6019/CHEMBL1961873 | Leukocyte tyrosine kinase receptor | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lck | 2 |
Data from ChEMBL 36 via Core Engine