Assay Detail
Binding
CHEMBL1002019
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Inhibition of VEGFR2 by HTRF assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.58 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496575 | — | — | 1 | 7.60 |
| CHEMBL524086 | — | — | 1 | 7.20 |
| CHEMBL496360 | — | — | 1 | 7.20 |
| CHEMBL495545 | — | — | 1 | 6.40 |
| CHEMBL495544 | — | — | 1 | 5.60 |
| CHEMBL524057 | GW683768X | — | 1 | 5.50 |
| CHEMBL525194 | — | — | 1 | - |
| CHEMBL498625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496575 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL524086 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL496360 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL495545 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL495544 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL524057 | GW683768X | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL525194 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL498625 | — | IC50 | > | 20000.0 | nM | - |