Assay Detail
Binding
CHEMBL1002074
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Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.12 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447810 | — | — | 1 | 5.26 |
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | 5.06 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.03 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
| CHEMBL229241 | SULFOSALICYLIC | -1.0 | 1 | - |
| CHEMBL1169 | AMINOSALICYLIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447810 | — | Ki | = | 5450.0 | nM | 5.26 |
| CHEMBL421 | SULFASALAZINE | Ki | = | 8720.0 | nM | 5.06 |
| CHEMBL898 | DIFLUNISAL | Ki | = | 9370.0 | nM | 5.03 |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 740000.0 | nM | - |
| CHEMBL25 | ASPIRIN | Ki | = | 3660000.0 | nM | - |
| CHEMBL229241 | SULFOSALICYLIC | Ki | = | 1920000.0 | nM | - |
| CHEMBL1169 | AMINOSALICYLIC ACID | Ki | = | 1230000.0 | nM | - |