Compound Detail
CHEMBL424
SALICYLIC ACID 🧪 Phase III
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL424 |
| Name | SALICYLIC ACID |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | YGSDEFSMJLZEOE-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
16
Targets
53
Activities
3
Assay Types
21
PK Parameters
20
Publications
30
Known Names
20
Indications
Molecular Properties
138.1
MW (Da)
1.09
ALogP
2
HBA
2
HBD
57.5
PSA (Ų)
0.61
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Acne Vulgaris Callosities Dandruff Dermatitis, Seborrheic Eye Diseases Inflammation Pruritus Psoriasis Skin Diseases Skin Neoplasms Sunburn Warts Acute Coronary Syndrome Cardiovascular Diseases Headache Keratosis, Actinic Pharyngitis Stroke Thrombophilia Thrombosis
ATC Classification
D01AE12
salicylic acid
Level 1: DERMATOLOGICALS
Level 2: ANTIFUNGALS FOR DERMATOLOGICAL USE
S01BC08
salicylic acid
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
Ki 35 meas. best 9.8
IC50 16 meas. best 6.7
Kd 2 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nicotinate phosphoribosyltransferase CHEMBL4523354 | Ki | 9.8 | 9.8 | 0.2 | 1 |
| Mus musculus CHEMBL375 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| High mobility group protein B1 CHEMBL2311236 | Kd | 6.0 | 6.0 | 1000.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 5.18 | 5.18 | 6600.0 | 1 |
| Carbonic anhydrase 2 CHEMBL205 | Ki | 5.15 | 5.15 | 7100.0 | 3 |
| Carbonic anhydrase 15 CHEMBL5973 | Ki | 5.14 | 5.14 | 7200.0 | 1 |
| Carbonic anhydrase 12 CHEMBL3242 | Ki | 5.06 | 5.06 | 8800.0 | 1 |
| Carbonic anhydrase 1 CHEMBL261 | Ki | 5.0 | 5.0 | 9900.0 | 3 |
| Carbonic anhydrase 4 CHEMBL3729 | Ki | 4.96 | 4.96 | 11100.0 | 1 |
| Carbonic anhydrase 6 CHEMBL3025 | Ki | 4.92 | 4.92 | 11900.0 | 1 |
| Solute carrier family 22 member 20 CHEMBL5269 | Ki | 4.36 | 4.36 | 43651.6 | 2 |
| Carbonic anhydrase 14 CHEMBL3510 | Ki | 4.3 | 4.3 | 49800.0 | 1 |
| Carbonic anhydrase 13 CHEMBL2186 | Ki | 4.17 | 4.17 | 67000.0 | 1 |
| Carbonic anhydrase 9 CHEMBL3594 | Ki | 4.1 | 4.1 | 78700.0 | 2 |
| Carbonic anhydrase 7 CHEMBL2326 | Ki | 4.09 | 4.09 | 82100.0 | 1 |
| Tyrosinase CHEMBL3318 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 99916.67 | ng.hr.mL-1 | Homo sapiens |
| AUC | 103333.33 | ng.hr.mL-1 | Homo sapiens |
| AUC | 263183.33 | ng.hr.mL-1 | Homo sapiens |
| AUC | 265566.67 | ng.hr.mL-1 | Homo sapiens |
| Cmax | 121633.36 | nM | Homo sapiens |
| Cmax | 246886.77 | nM | Homo sapiens |
| F | 80.0 | % | Homo sapiens |
| F | 100.0 | % | Homo sapiens |
| F | 100.0 | % | Homo sapiens |
| Fu | 0.28 | - | Rattus norvegicus |
| Fu | 0.63 | - | Rattus norvegicus |
| T1/2 | 17.6 | hr | Homo sapiens |
| T1/2 | 0.001333 | hr | Homo sapiens |
| T1/2 | 2.683 | hr | Homo sapiens |
| T1/2 | 2.75 | hr | Homo sapiens |
| T1/2 | 3.0 | hr | Homo sapiens |
| Tlag | 4.0 | min | Homo sapiens |
| Tlag | 3.0 | min | Homo sapiens |
| Tmax | 2.5 | hr | Homo sapiens |
| Tmax | 3.0 | hr | Homo sapiens |
| Vd | 1.0 | L.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine