Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL933691

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 15 (CHEMBL5973)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Innocenti A, Hilvo M, Scozzafava A, Parkkila S, Supuran CT.
Bioorg Med Chem Lett (2008) 18 : 3593 -3596
PubMed 18501600 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.32 7.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.14
CHEMBL497 CLIOQUINOL 4.0 1 5.63
CHEMBL424 SALICYLIC ACID 3.0 1 5.14
CHEMBL112 ACETAMINOPHEN 4.0 1 5.04
CHEMBL441343 PARABEN 1 5.03
CHEMBL280998 CATECHOL 1 4.99
CHEMBL14060 PHENOL 4.0 1 4.98
CHEMBL537 HYDROQUINONE 4.0 1 4.97
CHEMBL259068 1 4.95
CHEMBL66381 4-CYANOPHENOL 1 -
CHEMBL1142 4-AMINOPHENOL 1 -
CHEMBL261219 1 -
CHEMBL24147 RESORCINOL -1.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE Ki = 72.0 nM 7.14
CHEMBL497 CLIOQUINOL Ki = 2330.0 nM 5.63
CHEMBL424 SALICYLIC ACID Ki = 7200.0 nM 5.14
CHEMBL112 ACETAMINOPHEN Ki = 9230.0 nM 5.04
CHEMBL441343 PARABEN Ki = 9320.0 nM 5.03
CHEMBL280998 CATECHOL Ki = 10200.0 nM 4.99
CHEMBL14060 PHENOL Ki = 10500.0 nM 4.98
CHEMBL537 HYDROQUINONE Ki = 10600.0 nM 4.97
CHEMBL259068 Ki = 11300.0 nM 4.95
CHEMBL66381 4-CYANOPHENOL Ki = 434000.0 nM -
CHEMBL1142 4-AMINOPHENOL Ki = 335000.0 nM -
CHEMBL261219 Ki = 212000.0 nM -
CHEMBL24147 RESORCINOL Ki = 385000.0 nM -