Compound Detail
CHEMBL537
HYDROQUINONE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL537 |
| Name | HYDROQUINONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | QIGBRXMKCJKVMJ-UHFFFAOYSA-N |
23
Targets
51
Activities
3
Assay Types
0
PK Parameters
20
Publications
10
Known Names
3
Indications
Molecular Properties
110.1
MW (Da)
1.10
ALogP
2
HBA
2
HBD
40.5
PSA (Ų)
0.49
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2002 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Hyperpigmentation Lentigo Melanosis
ATC Classification
D11AX11
hydroquinone
Level 1: DERMATOLOGICALS
Level 2: OTHER DERMATOLOGICAL PREPARATIONS
Activity Summary
IC50 32 meas. best 6.0
Ki 18 meas. best 8.91
EC50 1 meas. best 4.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acetylcholinesterase CHEMBL4078 | Ki | 8.91 | 8.91 | 1.2 | 1 |
| Carbonic anhydrase 2 CHEMBL205 | Ki | 7.05 | 7.05 | 90.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 6.0 | 5.2275 | 1005.6 | 4 |
| Mushroom tyrosinase CHEMBL6066154 | IC50 | 5.96 | 5.96 | 1100.0 | 2 |
| Melan-a CHEMBL4296474 | IC50 | 5.4 | 5.4 | 3970.0 | 1 |
| Molecular identity unknown CHEMBL612546 | IC50 | 5.38 | 5.38 | 4210.0 | 1 |
| Carbonic anhydrase CHEMBL1795125 | Ki | 5.23 | 5.23 | 5930.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.2 | 5.2 | 6300.0 | 1 |
| Carbonic anhydrase 12 CHEMBL3242 | Ki | 5.11 | 5.11 | 7800.0 | 1 |
| Carbonic anhydrase 3 CHEMBL2885 | Ki | 5.09 | 5.09 | 8200.0 | 1 |
| Tyrosinase CHEMBL3318 | IC50 | 5.01 | 4.7083 | 9810.0 | 6 |
| Carbonic anhydrase 4 CHEMBL3729 | Ki | 4.97 | 4.97 | 10800.0 | 1 |
| Carbonic anhydrase 1 CHEMBL261 | Ki | 4.97 | 4.97 | 10700.0 | 2 |
| Carbonic anhydrase 15 CHEMBL5973 | Ki | 4.97 | 4.97 | 10600.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.9 | 4.9 | 12589.2 | 5 |
| Carbonic anhydrase 5B, mitochondrial CHEMBL3969 | Ki | 4.9 | 4.9 | 12500.0 | 1 |
| Carbonic anhydrase 5A, mitochondrial CHEMBL4789 | Ki | 4.85 | 4.85 | 14100.0 | 1 |
| ADMET CHEMBL612558 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
| Tyrosinase CHEMBL1973 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 4.71 | 4.71 | 19460.0 | 1 |
| Carbonic anhydrase 9 CHEMBL3594 | Ki | 4.49 | 4.49 | 32500.0 | 1 |
| Carbonic anhydrase 14 CHEMBL3510 | Ki | 4.38 | 4.38 | 42000.0 | 1 |
| U-251 CHEMBL615022 | EC50 | 4.24 | 4.24 | 57000.0 | 1 |
| Carbonic anhydrase 13 CHEMBL2186 | Ki | 4.13 | 4.13 | 74300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine