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Assay Detail

CHEMBL1924253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhagic lesion formation compound incubated with venom for 10 mins and administered subcutaneously measured after 24 hrs
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Confidence 1 — Organism
Curated By Autocuration

Target

Mus musculus (CHEMBL375)
Type ORGANISM
Organism Mus musculus

Publication

Benzenepolycarboxylic acids with potential anti-hemorrhagic properties and structure-activity relationships.
Aung HT, Nikai T, Niwa M, Takaya Y.
Bioorg Med Chem (2011) 19 : 7000 -7002
PubMed 22047800 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.90 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1235346 PYROMELLITIC ACID 1 7.46
CHEMBL1231329 MELLITIC ACID 1 7.37
CHEMBL1922186 BENZENEPENTACARBOXYLIC ACID 1 7.37
CHEMBL296024 1 7.21
CHEMBL77562 1 7.17
CHEMBL1374420 TEREPHTHALIC ACID 1 7.05
CHEMBL1045 PHTHALIC ACID 1 7.00
CHEMBL1871181 ISOPHTHALIC ACID 1 7.00
CHEMBL1922185 1 6.96
CHEMBL145 CAFFEIC ACID 3.0 1 6.72
CHEMBL541 BENZOIC ACID -1.0 1 6.70
CHEMBL441343 PARABEN 1 6.70
CHEMBL65369 3-HYDROXYBENZOIC ACID 1 6.70
CHEMBL424 SALICYLIC ACID 3.0 1 6.70
CHEMBL21708 4-METHYLBENZOIC ACID 1 6.66
CHEMBL618 4-CHLORO-BENZOIC ACID 1 6.62
CHEMBL101263 4-NITROBENZOIC ACID 1 6.62
CHEMBL115243 1 6.60
CHEMBL114719 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1235346 PYROMELLITIC ACID IC50 = 35.0 nM 7.46
CHEMBL1231329 MELLITIC ACID IC50 = 43.0 nM 7.37
CHEMBL1922186 BENZENEPENTACARBOXYLIC ACID IC50 = 43.0 nM 7.37
CHEMBL296024 IC50 = 62.0 nM 7.21
CHEMBL77562 IC50 = 67.0 nM 7.17
CHEMBL1374420 TEREPHTHALIC ACID IC50 = 90.0 nM 7.05
CHEMBL1045 PHTHALIC ACID IC50 = 100.0 nM 7.00
CHEMBL1871181 ISOPHTHALIC ACID IC50 = 100.0 nM 7.00
CHEMBL1922185 IC50 = 110.0 nM 6.96
CHEMBL145 CAFFEIC ACID IC50 = 190.0 nM 6.72
CHEMBL541 BENZOIC ACID IC50 = 200.0 nM 6.70
CHEMBL441343 PARABEN IC50 = 200.0 nM 6.70
CHEMBL65369 3-HYDROXYBENZOIC ACID IC50 = 200.0 nM 6.70
CHEMBL424 SALICYLIC ACID IC50 = 200.0 nM 6.70
CHEMBL21708 4-METHYLBENZOIC ACID IC50 = 220.0 nM 6.66
CHEMBL618 4-CHLORO-BENZOIC ACID IC50 = 240.0 nM 6.62
CHEMBL101263 4-NITROBENZOIC ACID IC50 = 240.0 nM 6.62
CHEMBL115243 IC50 = 250.0 nM 6.60
CHEMBL114719 IC50 = 260.0 nM 6.58