Assay Detail
Binding
CHEMBL3637535
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.71 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 5.26 |
| CHEMBL112 | ACETAMINOPHEN | 4.0 | 1 | 5.21 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | 5.15 |
| CHEMBL280998 | CATECHOL | — | 1 | 5.00 |
| CHEMBL3633783 | — | — | 1 | - |
| CHEMBL3633782 | — | — | 1 | - |
| CHEMBL3633781 | — | — | 1 | - |
| CHEMBL3633780 | — | — | 1 | - |
| CHEMBL3633779 | — | — | 1 | - |
| CHEMBL3633778 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL14060 | PHENOL | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL112 | ACETAMINOPHEN | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL280998 | CATECHOL | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL3633783 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633782 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633781 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633780 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633779 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633778 | — | Ki | > | 10000.0 | nM | - |