Assay Detail
Binding
CHEMBL1008236
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Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr
80
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 80 | 4.71 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | 4.0 | 2 | 5.96 |
| CHEMBL376503 | — | — | 2 | 5.36 |
| CHEMBL1162485 | 2-ETHYLHEXANOIC ACID | — | 2 | 5.18 |
| CHEMBL1162487 | — | — | 1 | 5.18 |
| CHEMBL1162486 | — | — | 1 | 5.18 |
| CHEMBL320358 | HEPTANOATE | — | 2 | 5.09 |
| CHEMBL897 | PROBENECID | 4.0 | 2 | 5.08 |
| CHEMBL14184 | HEXANOATE | — | 2 | 5.05 |
| CHEMBL541 | BENZOIC ACID | -1.0 | 2 | 4.86 |
| CHEMBL548 | DINOPROSTONE | 4.0 | 2 | 4.75 |
| CHEMBL1162488 | PHENYLPYRUVATE | — | 2 | 4.54 |
| CHEMBL568737 | 3-METHYLBUTANOIC ACID | — | 2 | 4.49 |
| CHEMBL1160012 | — | — | 2 | 4.39 |
| CHEMBL1162482 | — | — | 1 | 4.39 |
| CHEMBL1162483 | — | — | 1 | 4.39 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 2 | 4.36 |
| CHEMBL589366 | 3R14S-OCHRATOXIN A | — | 2 | 4.31 |
| CHEMBL494753 | ESTRONE SULFURIC ACID | 4.0 | 2 | 4.24 |
| CHEMBL607712 | 4-HYDROXYPHENYLPYRUVIC ACID | — | 2 | 4.18 |
| CHEMBL14227 | BUTYRIC ACID | 2.0 | 2 | 4.09 |
| CHEMBL1057 | FLUORESCEIN | 4.0 | 2 | 4.00 |
| CHEMBL25 | ASPIRIN | 4.0 | 2 | - |
| CHEMBL1162490 | — | — | 1 | - |
| CHEMBL34259 | METHOTREXATE | 4.0 | 2 | - |
| CHEMBL1162496 | 3-HYDROXYBUTYRIC ACID, (+/-)- | 1.0 | 2 | - |
| CHEMBL14021 | PROPIONIC ACID | 2.0 | 2 | - |
| CHEMBL1162144 | PYRUVATE | 2.0 | 2 | - |
| CHEMBL503160 | FUMARIC ACID | 3.0 | 2 | - |
| CHEMBL1162481 | DEAMINOHYDROXYVALINE | — | 1 | - |
| CHEMBL1162480 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521 | IBUPROFEN | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL521 | IBUPROFEN | Ki | = | 1122.02 | nM | 5.95 |
| CHEMBL376503 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL376503 | — | Ki | = | 4365.16 | nM | 5.36 |
| CHEMBL1162485 | 2-ETHYLHEXANOIC ACID | Ki | = | 6606.93 | nM | 5.18 |
| CHEMBL1162486 | — | Ki | = | 6606.93 | nM | 5.18 |
| CHEMBL1162487 | — | Ki | = | 6606.93 | nM | 5.18 |
| CHEMBL1162485 | 2-ETHYLHEXANOIC ACID | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL320358 | HEPTANOATE | Ki | = | 8128.31 | nM | 5.09 |
| CHEMBL320358 | HEPTANOATE | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL897 | PROBENECID | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL897 | PROBENECID | Ki | = | 8511.38 | nM | 5.07 |
| CHEMBL14184 | HEXANOATE | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL14184 | HEXANOATE | Ki | = | 9120.11 | nM | 5.04 |
| CHEMBL541 | BENZOIC ACID | Ki | = | 13800.0 | nM | 4.86 |
| CHEMBL541 | BENZOIC ACID | Ki | = | 13803.84 | nM | 4.86 |
| CHEMBL548 | DINOPROSTONE | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL548 | DINOPROSTONE | Ki | = | 18197.01 | nM | 4.74 |
| CHEMBL1162488 | PHENYLPYRUVATE | Ki | = | 28840.32 | nM | 4.54 |
| CHEMBL1162488 | PHENYLPYRUVATE | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL568737 | 3-METHYLBUTANOIC ACID | Ki | = | 32300.0 | nM | 4.49 |
| CHEMBL568737 | 3-METHYLBUTANOIC ACID | Ki | = | 32359.37 | nM | 4.49 |
| CHEMBL1162483 | — | Ki | = | 40738.03 | nM | 4.39 |
| CHEMBL1162482 | — | Ki | = | 40738.03 | nM | 4.39 |
| CHEMBL1160012 | — | Ki | = | 40738.03 | nM | 4.39 |
| CHEMBL1160012 | — | Ki | = | 40700.0 | nM | 4.39 |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 43651.58 | nM | 4.36 |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL589366 | 3R14S-OCHRATOXIN A | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL589366 | 3R14S-OCHRATOXIN A | Ki | = | 48977.88 | nM | 4.31 |
| CHEMBL494753 | ESTRONE SULFURIC ACID | Ki | = | 57543.99 | nM | 4.24 |
| CHEMBL494753 | ESTRONE SULFURIC ACID | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL607712 | 4-HYDROXYPHENYLPYRUVIC ACID | Ki | = | 66069.34 | nM | 4.18 |
| CHEMBL607712 | 4-HYDROXYPHENYLPYRUVIC ACID | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL14227 | BUTYRIC ACID | Ki | = | 81283.05 | nM | 4.09 |
| CHEMBL14227 | BUTYRIC ACID | Ki | = | 82000.0 | nM | 4.09 |
| CHEMBL1057 | FLUORESCEIN | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL1057 | FLUORESCEIN | Ki | = | 99000.0 | nM | 4.00 |
| CHEMBL25 | ASPIRIN | Ki | = | 102329.3 | nM | - |
| CHEMBL25 | ASPIRIN | Ki | = | 101000.0 | nM | - |
| CHEMBL1162496 | 3-HYDROXYBUTYRIC ACID, (+/-)- | Ki | = | 190546.07 | nM | - |
| CHEMBL1162496 | 3-HYDROXYBUTYRIC ACID, (+/-)- | Ki | = | 191000.0 | nM | - |
| CHEMBL14021 | PROPIONIC ACID | Ki | = | 281838.29 | nM | - |
| CHEMBL14021 | PROPIONIC ACID | Ki | = | 279000.0 | nM | - |
| CHEMBL1162490 | — | Ki | = | 181970.09 | nM | - |
| CHEMBL1162144 | PYRUVATE | Ki | = | 269153.48 | nM | - |
| CHEMBL1162144 | PYRUVATE | Ki | = | 271000.0 | nM | - |
| CHEMBL1162479 | — | Ki | = | 316227.77 | nM | - |
| CHEMBL461 | HIPPURIC ACID | Ki | = | 312000.0 | nM | - |
| CHEMBL1162492 | ESTRADIOL DISULFATE | Ki | = | 7210000.0 | nM | - |