Compound Detail
CHEMBL1162144
PYRUVATE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1162144 |
| Name | PYRUVATE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | LCTONWCANYUPML-UHFFFAOYSA-N |
1
Targets
7
Activities
1
Assay Types
0
PK Parameters
20
Publications
5
Known Names
4
Indications
Molecular Properties
88.1
MW (Da)
-0.34
ALogP
2
HBA
1
HBD
54.4
PSA (Ų)
0.45
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Glaucoma, Open-Angle Breast Neoplasms Ovarian Neoplasms Prostatic Neoplasms
Activity Summary
Ki 7 meas. best 4.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monocarboxylate transporter 2 CHEMBL2073718 | Ki | 4.1 | 4.1 | 80000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monocarboxylate transporter 2 | Ki | = | 80000.0 | nM | 4.1 | TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes | 10417314 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37252106 | 10.1039/d3md00058c | Unchecked | 4 |
| 37252106 | 10.1039/d3md00058c | Putative citrate synthase 2 | 3 |
| 11278508 | 10.1074/jbc.m009462200 | Monocarboxylate transporter 10 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.1039/C9MD00107G | 4-hydroxy-tetrahydrodipicolinate synthase | 2 |
| 17553798 | 10.1074/jbc.m703467200 | Solute carrier family 22 member 20 | 2 |
| 17553798 | 10.1074/jbc.m703467200 | Solute carrier family 22 member 6 | 2 |
| 9639576 | 10.1042/bj3330167 | Monocarboxylate transporter 1 | 1 |
| 11101640 | 10.1111/j.1469-7793.2000.00285.x | Monocarboxylate transporter 4 | 1 |
| 9786900 | 10.1074/jbc.273.44.28959 | Monocarboxylate transporter 1 | 1 |
| 18054225 | 10.1016/j.bmcl.2007.11.026 | Unchecked | 1 |
| 11827462 | 10.1006/geno.2001.6678 | SLC16A10 protein | 1 |
| 11997326 | 10.1152/ajprenal.00151.2001 | Solute carrier organic anion transporter family member 2A1 | 1 |
| 23547775 | 10.1021/jm400193d | Alpha-ketoglutarate-dependent dioxygenase FTO | 1 |
| 27156192 | 10.1016/j.bmc.2016.04.037 | C-terminal-binding protein 2 | 1 |
| 10417314 | 10.1042/0264-6021:3410529 | Monocarboxylate transporter 2 | 1 |
| 9786900 | 10.1074/jbc.273.44.28959 | Monocarboxylate transporter 2 | 1 |
| 9374487 | 10.1074/jbc.272.48.30096 | Monocarboxylate transporter 1 | 1 |
Data from ChEMBL 36 via Core Engine