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Target Snapshot

CHEMBL2073718 Target Snapshot

Monocarboxylate transporter 2 · SINGLE PROTEIN · Rattus norvegicus

23Compounds
3Assays
1Approved Drugs
10.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q63344. Use UniProt Q63344 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q63344 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Monocarboxylate transporter 2 as ChEMBL target CHEMBL2073718, mapped to UniProt Q63344. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Monocarboxylate transporter 2
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL2073718
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q63344
Monocarboxylate transporter 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Monocarboxylate transporter 2 is the right protein anchor across sources, using UniProt Q63344 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMonocarboxylate transporter 2
UniProt AccessionQ63344
Component TypeProtein
Sequence Length489 aa

Monocarboxylate transporter 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Monocarboxylate transporter 2, mapped to UniProt Q63344. Sequence length is 489 aa.

Mapped IDQ63344
Review nameMonocarboxylate transporter 2
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC504.0
KI6.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL50 5.3 IC50 5000.0 Clinical
CHEMBL388590 5.05 IC50 9000.0 Approved
CHEMBL45068 4.85 IC50 14000.0 Preclinical
CHEMBL76602 4.62 IC50 24000.0 Preclinical
CHEMBL1162144 4.1 Ki 80000.0 Clinical
CHEMBL445647 4.0 Ki 100000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

3
Total Assays
9
Tested Compounds
2
Assay Types
Binding — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0
Functional — 1 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 9 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine