Assay Detail
Functional
CHEMBL2076210
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TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes
27
Total Activities
23
Compounds Tested
4
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Monocarboxylate transporter 2 (CHEMBL2073718) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 17 | - | - |
| Ki | 5 | 4.05 | 4.10 |
| IC50 | 4 | 4.96 | 5.30 |
| Km | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | 3.0 | 2 | 5.30 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 2 | 5.05 |
| CHEMBL45068 | PHLORETIN | — | 2 | 4.85 |
| CHEMBL76602 | alpha-CYANO-4-HYDROXYCINNAMIC ACID | — | 2 | 4.62 |
| CHEMBL1162144 | PYRUVATE | 2.0 | 1 | 4.10 |
| CHEMBL445647 | 2-Oxoisohexanoate | — | 1 | 4.00 |
| CHEMBL173439 | — | — | 1 | - |
| CHEMBL445874 | ADAMANTANEACETIC ACID | — | 1 | - |
| CHEMBL1609 | MANDELIC ACID | -1.0 | 1 | - |
| CHEMBL1909428 | p-Chloromercuribenzenesulfonate | — | 1 | - |
| CHEMBL2074646 | — | — | 1 | - |
| CHEMBL458328 | — | — | 1 | - |
| CHEMBL63323 | NIFLUMIC ACID | 2.0 | 1 | - |
| CHEMBL1256759 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] | — | 1 | - |
| CHEMBL121047 | DIBENZYL DISULFIDE | — | 1 | - |
| CHEMBL1374360 | MERCURIC CHLORIDE | -1.0 | 1 | - |
| CHEMBL107057 | — | — | 1 | - |
| CHEMBL897 | PROBENECID | 4.0 | 1 | - |
| CHEMBL146554 | 2-Oxoisovalerate | — | 1 | - |
| CHEMBL1230762 | ACETOACETIC ACID | -1.0 | 1 | - |
| CHEMBL1162496 | 3-HYDROXYBUTYRIC ACID, (+/-)- | 1.0 | 1 | - |
| CHEMBL1513985 | ANTHRACENE-9-CARBOXYLIC ACID | — | 1 | - |
| CHEMBL358850 | D-LACTIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL45068 | PHLORETIN | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL76602 | alpha-CYANO-4-HYDROXYCINNAMIC ACID | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1162144 | PYRUVATE | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL445647 | 2-Oxoisohexanoate | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL173439 | — | Activity | = | 105.0 | % | - |
| CHEMBL445874 | ADAMANTANEACETIC ACID | Activity | = | 113.0 | % | - |
| CHEMBL1609 | MANDELIC ACID | Activity | = | 117.0 | % | - |
| CHEMBL1909428 | p-Chloromercuribenzenesulfonate | Activity | = | 118.0 | % | - |
| CHEMBL2074646 | — | Activity | = | 119.0 | % | - |
| CHEMBL388590 | BENZBROMARONE | Activity | = | 12.0 | % | - |
| CHEMBL458328 | — | Activity | = | 125.0 | % | - |
| CHEMBL63323 | NIFLUMIC ACID | Activity | = | 14.0 | % | - |
| CHEMBL50 | QUERCETIN | Activity | = | 17.0 | % | - |
| CHEMBL1256759 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] | Activity | = | 25.0 | % | - |
| CHEMBL45068 | PHLORETIN | Activity | = | 3.0 | % | - |
| CHEMBL76602 | alpha-CYANO-4-HYDROXYCINNAMIC ACID | Activity | = | 34.0 | % | - |
| CHEMBL1513985 | ANTHRACENE-9-CARBOXYLIC ACID | Activity | = | 104.0 | % | - |
| CHEMBL1374360 | MERCURIC CHLORIDE | Activity | = | 54.0 | % | - |
| CHEMBL107057 | — | Activity | = | 74.0 | % | - |
| CHEMBL897 | PROBENECID | Activity | = | 88.0 | % | - |
| CHEMBL146554 | 2-Oxoisovalerate | Ki | = | 300000.0 | nM | - |
| CHEMBL1230762 | ACETOACETIC ACID | Ki | = | 800000.0 | nM | - |
| CHEMBL1162496 | 3-HYDROXYBUTYRIC ACID, (+/-)- | Ki | = | 1200000.0 | nM | - |
| CHEMBL358850 | D-LACTIC ACID | Km | = | 740000.0 | nM | - |
| CHEMBL121047 | DIBENZYL DISULFIDE | Activity | = | 44.0 | % | - |