Assay Detail
Binding
CHEMBL4418184
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Inhibition of NAPRT (unknown origin)
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinate phosphoribosyltransferase (CHEMBL4523354) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 9.44 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 11.00 |
| CHEMBL686 | MEFENAMIC ACID | 4.0 | 1 | 10.30 |
| CHEMBL613 | PYRAZINOIC ACID | -1.0 | 1 | 10.12 |
| CHEMBL101 | PHENYLBUTAZONE | 4.0 | 1 | 10.00 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 9.82 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | 9.80 |
| CHEMBL53297 | — | — | 1 | 9.64 |
| CHEMBL394308 | — | — | 1 | 9.55 |
| CHEMBL1228 | OXYPHENBUTAZONE ANHYDROUS | 4.0 | 1 | 9.52 |
| CHEMBL832 | SULFINPYRAZONE | 4.0 | 1 | 9.30 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 9.30 |
| CHEMBL1723657 | 6-CHLORONICOTINIC ACID | — | 1 | 9.25 |
| CHEMBL1203 | ISONICOTINIC ACID | -1.0 | 1 | 9.12 |
| CHEMBL4438353 | — | — | 1 | 9.12 |
| CHEMBL266158 | PYRIDINE | — | 1 | 9.11 |
| CHEMBL3322868 | — | — | 1 | 9.09 |
| CHEMBL269644 | ACETANILIDE | 4.0 | 1 | 9.00 |
| CHEMBL288470 | AMINOPYRINE | 4.0 | 1 | 9.00 |
| CHEMBL277474 | ANTIPYRINE | 3.0 | 1 | 9.00 |
| CHEMBL72628 | 2-PICOLINIC ACID | — | 1 | 8.94 |
| CHEMBL1741437 | — | — | 1 | 8.89 |
| CHEMBL541 | BENZOIC ACID | -1.0 | 1 | 8.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23588 | FLUFENAMIC ACID | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL686 | MEFENAMIC ACID | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL613 | PYRAZINOIC ACID | Ki | = | 0.075 | nM | 10.12 |
| CHEMBL101 | PHENYLBUTAZONE | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL6 | INDOMETHACIN | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL53297 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL394308 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL1228 | OXYPHENBUTAZONE ANHYDROUS | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL832 | SULFINPYRAZONE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL25 | ASPIRIN | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1723657 | 6-CHLORONICOTINIC ACID | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL1203 | ISONICOTINIC ACID | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL4438353 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL266158 | PYRIDINE | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL3322868 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL269644 | ACETANILIDE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL288470 | AMINOPYRINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL277474 | ANTIPYRINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL72628 | 2-PICOLINIC ACID | Ki | = | 1.16 | nM | 8.94 |
| CHEMBL1741437 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL541 | BENZOIC ACID | Ki | = | 1.9 | nM | 8.72 |