Compound Detail
CHEMBL266158
PYRIDINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL266158 |
| Name | PYRIDINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JUJWROOIHBZHMG-UHFFFAOYSA-N |
1
Targets
6
Activities
4
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
79.1
MW (Da)
1.08
ALogP
1
HBA
0
HBD
12.9
PSA (Ų)
0.45
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 3 meas.
EC50 1 meas.
IC50 1 meas.
Ki 1 meas. best 9.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nicotinate phosphoribosyltransferase CHEMBL4523354 | Ki | 9.11 | 9.11 | 0.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nicotinate phosphoribosyltransferase | Ki | = | 0.78 | nM | 9.11 | Inhibition of NAPRT (unknown origin) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3885881 | Rattus norvegicus | 148 |
| 3599019 | 10.1021/jm00390a002 | No relevant target | 6 |
| 4032427 | 10.1021/jm00147a021 | Neuronal acetylcholine receptor | 5 |
| 26371436 | 10.1021/acs.jmedchem.5b01146 | Cytochrome P450 3A4 | 4 |
| 18558667 | 10.1021/jm701549s | No relevant target | 4 |
| 19284751 | 10.1021/jm8012757 | Heme | 4 |
| 23473072 | 10.1021/jm301823g | Endolysin | 2 |
| 9526560 | 10.1021/jm9704311 | ADMET | 2 |
| 1271403 | 10.1021/jm00227a008 | No relevant target | 2 |
| - | 10.1016/0960-894X(95)00226-J | No relevant target | 2 |
| 15857133 | 10.1021/jm048980b | No relevant target | 1 |
| 22300887 | 10.1016/j.bmc.2012.01.014 | No relevant target | 1 |
| 19222165 | 10.1021/jm8012618 | Heme | 1 |
| 17300161 | 10.1021/jm0611105 | ADMET | 1 |
| 17300161 | 10.1021/jm0611105 | No relevant target | 1 |
| 10866370 | 10.1016/s0960-894x(00)00172-4 | No relevant target | 1 |
| 2033592 | 10.1021/jm00109a021 | Lithobates pipiens | 1 |
| 2033592 | 10.1021/jm00109a021 | ADMET | 1 |
| 3882967 | 10.1021/jm00381a013 | No relevant target | 1 |
| 37014977 | 10.1021/acs.jmedchem.2c02015 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine