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Evidence Snapshot

Nicotinate phosphoribosyltransferase

CHEMBL4523354 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T23:51:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4523354
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Nicotinate phosphoribosyltransferase as ChEMBL target CHEMBL4523354, mapped to UniProt Q6XQN6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Nicotinate phosphoribosyltransferase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4523354
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q6XQN6
Nicotinate phosphoribosyltransferase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Nicotinate phosphoribosyltransferase matters

As of 2026-09-13

Nicotinate phosphoribosyltransferase is reviewed as Nicotinate phosphoribosyltransferase (UniProt Q6XQN6); the current evidence base includes 8 approved drugs, 23 compounds, and 16 assays, with lead potency reaching pChEMBL 11.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 8 approved drugs, 23 compounds, and 16 assays for this target. The dominant activity type is KI. CHEMBL23588 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL23588 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
8 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Nicotinate phosphoribosyltransferase matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q6XQN6, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

23
Total Compounds
16
Total Assays
8
Approved Drugs
KI: 22.0, KD: 1.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL23588
 11.0 Ki Clinical
No preferred name
CHEMBL686
 10.3 Ki Approved
No preferred name
CHEMBL613
 10.1 Ki —
No preferred name
CHEMBL101
 10.0 Ki Approved
No preferred name
CHEMBL6
 9.8 Ki Approved

Approved Drugs

Structure Compound First Approval
PHENYLBUTAZONE
CHEMBL101
 1980
MEFENAMIC ACID
CHEMBL686
 1967
INDOMETHACIN
CHEMBL6
 1965
OXYPHENBUTAZONE ANHYDROUS
CHEMBL1228
 1960
SULFINPYRAZONE
CHEMBL832
 1959
ASPIRIN
CHEMBL25
 1950
ACETANILIDE
CHEMBL269644
 —
AMINOPYRINE
CHEMBL288470
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T23:51:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4523354