Assay Detail
Functional
CHEMBL1002211
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Antiviral activity against NNRTI-resistant HIV1 with reverse transcriptase G190A mutant in HeLa cells by MAGI assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.21 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203420 | — | — | 1 | 9.22 |
| CHEMBL275658 | — | — | 1 | 8.40 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.23 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 7.68 |
| CHEMBL296939 | — | — | 1 | 7.51 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203420 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL275658 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL296939 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 2000.0 | nM | - |