Assay Detail
ADMET
CHEMBL1002236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP2C19 expressed in insect microsomes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.00 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500394 | — | — | 1 | 5.45 |
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 5.22 |
| CHEMBL453169 | — | — | 1 | 4.34 |
| CHEMBL502824 | — | — | 1 | - |
| CHEMBL447591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500394 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL3989843 | TRANYLCYPROMINE | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL453169 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL502824 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL447591 | — | IC50 | > | 25000.0 | nM | - |