Assay Detail
Functional
CHEMBL1002589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.28 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.40 |
| CHEMBL458904 | PATENTIFLORIN A | — | 1 | 7.92 |
| CHEMBL505932 | — | — | 1 | 7.80 |
| CHEMBL454803 | 4'-O-ACETYLPATENTIFLORIN B | — | 1 | 7.52 |
| CHEMBL444750 | — | — | 1 | 7.46 |
| CHEMBL458905 | PATENTIFLORIN B | — | 1 | 6.60 |
| CHEMBL449447 | — | — | 1 | 6.58 |
| CHEMBL452903 | 4'-O-ACETYLMANANTHOSIDE B | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL458904 | PATENTIFLORIN A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL505932 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL454803 | 4'-O-ACETYLPATENTIFLORIN B | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL444750 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL458905 | PATENTIFLORIN B | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL449447 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL452903 | 4'-O-ACETYLMANANTHOSIDE B | IC50 | = | 1200.0 | nM | 5.92 |