Assay Detail
Binding
CHEMBL1002724
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Binding affinity to mouse AChE
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.19 | 4.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1652 | AMBENONIUM | 4.0 | 1 | 4.27 |
| CHEMBL538358 | DECIDIUM | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1652 | AMBENONIUM | Kd | = | 54000.0 | nM | 4.27 |
| CHEMBL538358 | DECIDIUM | Kd | = | 79000.0 | nM | 4.10 |