Assay Detail
Functional
CHEMBL1002741
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Cytotoxicity against human U87MG cells after 3 days by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.44 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL448558 | LANTALUCRATIN B | — | 1 | 5.72 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.70 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | — | 1 | 5.58 |
| CHEMBL510369 | — | — | 1 | 5.47 |
| CHEMBL447062 | LANTALUCRATIN A | — | 1 | 5.33 |
| CHEMBL487397 | LANTALUCRATIN E | — | 1 | 5.16 |
| CHEMBL470256 | LANTALUCRATIN C | — | 1 | 5.14 |
| CHEMBL451534 | LANTALUCRATIN D | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL448558 | LANTALUCRATIN B | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL221630 | DEHYDROISO-ALPHA-LAPACHONE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL510369 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL447062 | LANTALUCRATIN A | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL487397 | LANTALUCRATIN E | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL470256 | LANTALUCRATIN C | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL451534 | LANTALUCRATIN D | IC50 | > | 10000.0 | nM | - |