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Assay Detail

CHEMBL1002943

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Binding
Inhibition of MMP1
34
Total Activities
34
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Georgiadis D, Yiotakis A.
Bioorg Med Chem (2008) 16 : 8781 -8794
PubMed 18790648 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.59 8.22
Ki 15 5.35 9.00
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL389020 1 9.00
CHEMBL98044 1 8.22
CHEMBL26913 1 7.19
CHEMBL71645 1 5.64
CHEMBL484261 1 5.61
CHEMBL50228 1 5.60
CHEMBL40143 1 5.34
CHEMBL523956 1 5.28
CHEMBL485492 1 5.27
CHEMBL503231 1 5.23
CHEMBL209970 1 5.06
CHEMBL251917 1 4.85
CHEMBL148169 1 4.52
CHEMBL262758 1 4.50
CHEMBL24398 1 4.48
CHEMBL484262 1 4.43
CHEMBL117225 1 4.29
CHEMBL507420 1 4.17
CHEMBL491643 1 -
CHEMBL434567 1 -
CHEMBL181244 1 -
CHEMBL270083 1 -
CHEMBL497772 1 -
CHEMBL497985 1 -
CHEMBL489603 1 -
CHEMBL483857 1 -
CHEMBL270050 1 -
CHEMBL325163 1 -
CHEMBL496527 1 -
CHEMBL207305 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL389020 Ki = 1.0 nM 9.00
CHEMBL98044 IC50 = 6.0 nM 8.22
CHEMBL26913 IC50 = 65.0 nM 7.19
CHEMBL71645 IC50 = 2268.0 nM 5.64
CHEMBL484261 IC50 = 2471.0 nM 5.61
CHEMBL50228 Ki = 2500.0 nM 5.60
CHEMBL40143 IC50 = 4600.0 nM 5.34
CHEMBL523956 Ki = 5248.0 nM 5.28
CHEMBL485492 Ki = 5400.0 nM 5.27
CHEMBL503231 IC50 = 5900.0 nM 5.23
CHEMBL209970 IC50 = 8780.0 nM 5.06
CHEMBL251917 IC50 = 14000.0 nM 4.85
CHEMBL148169 Ki = 30000.0 nM 4.52
CHEMBL262758 Ki = 32000.0 nM 4.50
CHEMBL24398 Ki = 33160.0 nM 4.48
CHEMBL484262 IC50 = 37300.0 nM 4.43
CHEMBL117225 IC50 = 51000.0 nM 4.29
CHEMBL507420 Ki = 67000.0 nM 4.17
CHEMBL491643 IC50 > 5000.0 nM -
CHEMBL434567 IC50 > 5000.0 nM -
CHEMBL181244 IC50 > 50000.0 nM -
CHEMBL270083 IC50 > 100000.0 nM -
CHEMBL497772 IC50 > 400000.0 nM -
CHEMBL497985 IC50 > 5000.0 nM -
CHEMBL489603 IC50 > 50000.0 nM -
CHEMBL483857 Ki = 206000.0 nM -
CHEMBL270050 Activity - -
CHEMBL325163 Ki > 2000.0 nM -
CHEMBL496527 Ki > 4949.0 nM -
CHEMBL207305 Ki > 4949.0 nM -
CHEMBL495502 Ki > 5000.0 nM -
CHEMBL253275 Ki > 10000.0 nM -
CHEMBL402393 Ki > 4946.0 nM -
CHEMBL318252 IC50 > 100000.0 nM -