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Target Snapshot

CHEMBL332 Target Snapshot

Interstitial collagenase · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
5,464Compounds
556Assays
6Approved Drugs
6,383.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Interstitial collagenase shows approved-linked disease relevance led by acne. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P03956. Start with acne, then reuse UniProt P03956 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with acne, then reuse UniProt P03956 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 2 linked drugs
Open source guide
Disease program
acne

Interstitial collagenase shows approved-linked disease relevance led by acne. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with acne because it currently carries approved-linked support. Linked drugs include DOXYCYCLINE, DOXYCYCLINE HYCLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Interstitial collagenase as ChEMBL target CHEMBL332, mapped to UniProt P03956. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Interstitial collagenase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL332
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P03956
Interstitial collagenase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Interstitial collagenase is the right protein anchor across sources, using UniProt P03956 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why acne is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameInterstitial collagenase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP03956
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelInterstitial collagenase
UniProt AccessionP03956
Component TypeProtein
Sequence Length469 aa

Interstitial collagenase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Interstitial collagenase, mapped to UniProt P03956. Sequence length is 469 aa.

Mapped IDP03956
Review nameInterstitial collagenase
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Interstitial collagenase shows approved-linked disease relevance led by acne. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
acne
2 linked drugs · 2 direct · 2 efficacy
Linked drugDOXYCYCLINE
Linked drugDOXYCYCLINE HYCLATE
Approved-linked Approved
malaria
2 linked drugs · 2 direct · 2 efficacy
Linked drugDOXYCYCLINE
Linked drugDOXYCYCLINE HYCLATE
Approved-linked Approved
periodontitis
2 linked drugs · 2 direct · 2 efficacy
Linked drugDOXYCYCLINE
Linked drugDOXYCYCLINE HYCLATE
Approved-linked Approved
rosacea
2 linked drugs · 2 direct · 2 efficacy
Linked drugDOXYCYCLINE
Linked drugDOXYCYCLINE HYCLATE
Approved-linked Approved
anthrax infection
1 linked drug · 1 direct · 1 efficacy
Linked drugDOXYCYCLINE
Approved-linked Approved
bacterial disease
1 linked drug · 1 direct · 1 efficacy
Linked drugDOXYCYCLINE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with acne because it currently carries approved-linked support. Linked drugs include DOXYCYCLINE, DOXYCYCLINE HYCLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseacne
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

6
Approved
7
Phase III
14
Phase II
Assay Mix

Activity Type Distribution

IC504,231.0
KI2,132.0
EC5018.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL281795 10.0 Ki 0.1 Preclinical
CHEMBL526566 10.0 EC50 0.1 Preclinical
CHEMBL19611 9.7 IC50 0.2 Clinical
CHEMBL321180 9.59 IC50 0.26 Preclinical
CHEMBL115653 9.52 Ki 0.3 Clinical
CHEMBL279078 9.52 IC50 0.3 Preclinical
CHEMBL141080 9.4 IC50 0.4 Preclinical
CHEMBL19611 9.4 Ki 0.4 Clinical
CHEMBL279786 9.4 IC50 0.4 Clinical
CHEMBL4088630 9.4 IC50 0.4 Preclinical
Distribution

pChEMBL Value Distribution

437
5.0
380
5.5
422
6.0
425
6.5
359
7.0
268
7.5
171
8.0
132
8.5
35
9.0
4
9.5
pChEMBL
Assay Landscape

Assay Landscape

556
Total Assays
2,709
Tested Compounds
3
Assay Types
Binding — 545 assays, 2,709 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 514 2,607 6.4
assay format 17 16 6.7
cell-based format 12 78 5.9
tissue-based format 2 8 6.5
ADME — 10 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 9 6 6.6
assay format 1 0 —
Toxicity — 1 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 3 6.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine