Compound Detail
CHEMBL4088630
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4088630 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ULILDPSFFUSXJH-UHFFFAOYSA-N |
7
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
360.5
MW (Da)
1.09
ALogP
6
HBA
2
HBD
95.9
PSA (Ų)
0.62
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 9.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interstitial collagenase CHEMBL332 | IC50 | 9.4 | 9.4 | 0.4 | 1 |
| Stromelysin-1 CHEMBL283 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
| Neutrophil collagenase CHEMBL4588 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
| Matrix metalloproteinase-9 CHEMBL321 | IC50 | 9.05 | 9.05 | 0.9 | 1 |
| Collagenase 3 CHEMBL280 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| 72 kDa type IV collagenase CHEMBL333 | IC50 | 8.85 | 8.85 | 1.4 | 1 |
| Matrilysin CHEMBL4073 | IC50 | 7.64 | 7.64 | 23.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interstitial collagenase | IC50 | = | 0.4 | nM | 9.4 | Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escher... | 28850227 |
| Stromelysin-1 | IC50 | = | 0.7 | nM | 9.15 | Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Esc... | 28850227 |
| Neutrophil collagenase | IC50 | = | 0.7 | nM | 9.15 | Inhibition of MMP8 (unknown origin) expressed in Escherichia coli BL21(DE3) usin... | 28850227 |
| Matrix metalloproteinase-9 | IC50 | = | 0.9 | nM | 9.05 | Inhibition of MMP9 (unknown origin) expressed in Escherichia coli BL21(DE3) usin... | 28850227 |
| Collagenase 3 | IC50 | = | 1.0 | nM | 9.0 | Inhibition of MMP13 (unknown origin) expressed in Escherichia coli BL21(DE3) usi... | 28850227 |
| 72 kDa type IV collagenase | IC50 | = | 1.4 | nM | 8.85 | Inhibition of MMP2 (unknown origin) expressed in Escherichia coli BL21(DE3) usin... | 28850227 |
| Matrilysin | IC50 | = | 23.0 | nM | 7.64 | Inhibition of MMP7 (unknown origin) expressed in Escherichia coli BL21(DE3) usin... | 28850227 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28850227 | 10.1021/acs.jmedchem.7b00315 | Matrix metalloproteinase-9 | 1 |
| 28850227 | 10.1021/acs.jmedchem.7b00315 | Matrilysin | 1 |
| 28850227 | 10.1021/acs.jmedchem.7b00315 | Stromelysin-1 | 1 |
| 28850227 | 10.1021/acs.jmedchem.7b00315 | Interstitial collagenase | 1 |
| 28850227 | 10.1021/acs.jmedchem.7b00315 | Neutrophil collagenase | 1 |
| 28850227 | 10.1021/acs.jmedchem.7b00315 | Collagenase 3 | 1 |
| 28850227 | 10.1021/acs.jmedchem.7b00315 | 72 kDa type IV collagenase | 1 |
Data from ChEMBL 36 via Core Engine