Assay Detail
Binding
CHEMBL4037094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MMP7 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 mins by spectrofluorimetric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.87 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4088630 | — | — | 1 | 7.64 |
| CHEMBL115727 | — | — | 1 | 7.52 |
| CHEMBL140970 | — | — | 1 | 7.52 |
| CHEMBL342210 | — | — | 1 | 7.39 |
| CHEMBL333729 | — | — | 1 | 6.34 |
| CHEMBL4067375 | — | — | 1 | 5.96 |
| CHEMBL345054 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4088630 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL115727 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL140970 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL342210 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL333729 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4067375 | — | IC50 | = | 1102.0 | nM | 5.96 |
| CHEMBL345054 | — | IC50 | = | 2027.0 | nM | 5.69 |