Assay Detail
Functional
CHEMBL1003011
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against chinese hamster RT16 cells expressing human folate receptor alpha after 96 hrs by celltiter-blue cell viability assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | RT16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.54 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491104 | — | — | 1 | 8.05 |
| CHEMBL490934 | — | — | 1 | 7.89 |
| CHEMBL491129 | — | — | 1 | 7.25 |
| CHEMBL491298 | — | — | 1 | 6.97 |
| CHEMBL522455 | — | — | 1 | - |
| CHEMBL522126 | — | — | 1 | - |
| CHEMBL491299 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491104 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL490934 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL491129 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL491298 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL522455 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL522126 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL491299 | — | IC50 | > | 1000.0 | nM | - |