Assay Detail
Functional
CHEMBL1003075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against NNRTI-resistant HIV1 with reverse transcriptase K103N/V108I mutant in HeLa cells by MAGI assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.78 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203420 | — | — | 1 | 9.05 |
| CHEMBL275658 | — | — | 1 | 8.59 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.03 |
| CHEMBL296939 | — | — | 1 | 6.46 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203420 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL275658 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL296939 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 2000.0 | nM | - |
| CHEMBL593 | DELAVIRDINE | IC50 | > | 2000.0 | nM | - |