Assay Detail
Binding
CHEMBL1003109
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Displacement of [3H]DAMGO from mu opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.10 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501451 | — | — | 1 | 9.80 |
| CHEMBL458631 | — | — | 1 | 9.80 |
| CHEMBL109390 | — | — | 1 | 9.30 |
| CHEMBL500937 | — | — | 1 | 8.76 |
| CHEMBL450263 | — | — | 1 | 8.23 |
| CHEMBL498799 | — | — | 1 | 8.13 |
| CHEMBL501202 | — | — | 1 | 7.97 |
| CHEMBL499099 | — | — | 1 | 7.93 |
| CHEMBL444197 | — | — | 1 | 7.79 |
| CHEMBL502302 | — | — | 1 | 7.35 |
| CHEMBL442577 | — | — | 1 | 7.27 |
| CHEMBL450566 | — | — | 1 | 6.51 |
| CHEMBL448360 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501451 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL458631 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL109390 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL500937 | — | Ki | = | 1.75 | nM | 8.76 |
| CHEMBL450263 | — | Ki | = | 5.93 | nM | 8.23 |
| CHEMBL498799 | — | Ki | = | 7.49 | nM | 8.13 |
| CHEMBL501202 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL499099 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL444197 | — | Ki | = | 16.1 | nM | 7.79 |
| CHEMBL502302 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL442577 | — | Ki | = | 53.9 | nM | 7.27 |
| CHEMBL450566 | — | Ki | = | 309.4 | nM | 6.51 |
| CHEMBL448360 | — | Ki | = | 364.3 | nM | 6.44 |