Assay Detail
Functional
CHEMBL1003111
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Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.75 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501451 | — | — | 1 | 8.59 |
| CHEMBL458631 | — | — | 1 | 8.57 |
| CHEMBL109390 | — | — | 1 | 7.57 |
| CHEMBL444197 | — | — | 1 | 6.75 |
| CHEMBL501202 | — | — | 1 | 6.58 |
| CHEMBL500937 | — | — | 1 | 5.83 |
| CHEMBL442577 | — | — | 1 | 5.76 |
| CHEMBL498799 | — | — | 1 | 5.58 |
| CHEMBL450263 | — | — | 1 | 5.54 |
| CHEMBL450566 | — | — | 1 | - |
| CHEMBL499099 | — | — | 1 | - |
| CHEMBL502302 | — | — | 1 | - |
| CHEMBL448360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501451 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL458631 | — | IC50 | = | 2.69 | nM | 8.57 |
| CHEMBL109390 | — | IC50 | = | 26.92 | nM | 7.57 |
| CHEMBL444197 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL501202 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL500937 | — | IC50 | = | 1466.0 | nM | 5.83 |
| CHEMBL442577 | — | IC50 | = | 1724.0 | nM | 5.76 |
| CHEMBL498799 | — | IC50 | = | 2655.0 | nM | 5.58 |
| CHEMBL450263 | — | IC50 | = | 2886.0 | nM | 5.54 |
| CHEMBL450566 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL499099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL502302 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL448360 | — | IC50 | > | 10000.0 | nM | - |