Assay Detail
Functional
CHEMBL1003112
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Antagonist activity at delta opioid receptor in mouse vas deferens assessed as effect on deltorphin 2-induced response
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 9.09 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450263 | — | — | 1 | 9.90 |
| CHEMBL442577 | — | — | 1 | 9.90 |
| CHEMBL499099 | — | — | 1 | 9.65 |
| CHEMBL501202 | — | — | 1 | 9.40 |
| CHEMBL458631 | — | — | 1 | 9.25 |
| CHEMBL500937 | — | — | 1 | 8.80 |
| CHEMBL448360 | — | — | 1 | 8.75 |
| CHEMBL498799 | — | — | 1 | 8.62 |
| CHEMBL450566 | — | — | 1 | 8.53 |
| CHEMBL502302 | — | — | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450263 | — | Kd | = | 0.1259 | nM | 9.90 |
| CHEMBL442577 | — | Kd | = | 0.1259 | nM | 9.90 |
| CHEMBL499099 | — | Kd | = | 0.2239 | nM | 9.65 |
| CHEMBL501202 | — | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL458631 | — | Kd | = | 0.5623 | nM | 9.25 |
| CHEMBL500937 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL448360 | — | Kd | = | 1.778 | nM | 8.75 |
| CHEMBL498799 | — | Kd | = | 2.399 | nM | 8.62 |
| CHEMBL450566 | — | Kd | = | 2.951 | nM | 8.53 |
| CHEMBL502302 | — | Kd | = | 8.71 | nM | 8.06 |