Assay Detail
Binding
CHEMBL1003656
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Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLC
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.55 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490292 | — | — | 1 | 9.52 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 8.52 |
| CHEMBL473946 | — | — | 1 | 8.52 |
| CHEMBL522267 | — | — | 1 | 8.22 |
| CHEMBL514950 | — | — | 1 | 8.00 |
| CHEMBL504541 | — | — | 1 | 7.70 |
| CHEMBL522624 | — | — | 1 | 7.70 |
| CHEMBL489899 | — | — | 1 | 7.52 |
| CHEMBL524133 | — | — | 1 | 7.40 |
| CHEMBL491089 | — | — | 1 | 7.16 |
| CHEMBL491088 | — | — | 1 | 7.00 |
| CHEMBL490889 | — | — | 1 | 6.70 |
| CHEMBL475545 | — | — | 1 | 6.70 |
| CHEMBL300982 | LICOFELONE | 2.0 | 1 | 6.70 |
| CHEMBL515547 | — | — | 1 | 6.22 |
| CHEMBL491090 | — | — | 1 | 6.00 |
| CHEMBL489898 | — | — | 1 | 5.70 |
| CHEMBL491477 | — | — | 1 | 5.16 |
| CHEMBL475347 | — | — | 1 | 5.10 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.10 |
| CHEMBL491272 | — | — | 1 | 5.10 |
| CHEMBL472722 | — | — | 1 | 4.70 |
| CHEMBL472721 | — | — | 1 | 4.70 |
| CHEMBL171646 | — | — | 1 | 4.30 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 4.30 |
| CHEMBL489702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490292 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL473946 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL522267 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL514950 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL504541 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL522624 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL489899 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL524133 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL491089 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL491088 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL490889 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL475545 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL300982 | LICOFELONE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL515547 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL491090 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL489898 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL491477 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL475347 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL118 | CELECOXIB | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL491272 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL472722 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL472721 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL171646 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL489702 | — | IC50 | > | 50000.0 | nM | - |