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Assay Detail

CHEMBL1003712

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human AChE by Lineweaver-Burke plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Marco-Contelles J, León R, de los Ríos C, Samadi A, Bartolini M, Andrisano V, Huertas O, Barril X, Luque FJ, Rodríguez-Franco MI, López B, López MG, García AG, Carreiras Mdo C, Villarroya M.
J Med Chem (2009) 52 : 2724 -2732
PubMed 19374444 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.96 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL374184 1 6.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL374184 Ki = 109.0 nM 6.96