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Assay Detail

CHEMBL1003776

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against pseudotype HIV after 2 days in presence 40 mg/mL human serum albumin
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus (CHEMBL613758)
Type ORGANISM
Organism Human immunodeficiency virus

Publication

Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.
Boros EE, Edwards CE, Foster SA, Fuji M, Fujiwara T, Garvey EP, Golden PL, Hazen RJ, Jeffrey JL, Johns BA, Kawasuji T, Kiyama R, Koble CS, Kurose N, Miller WH, Mote AL, Murai H, Sato A, Thompson JB, Woodward MC, Yoshinaga T.
J Med Chem (2009) 52 : 2754 -2761
PubMed 19374386 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.56 7.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL492188 1 7.44
CHEMBL491347 1 7.30
CHEMBL522802 1 7.24
CHEMBL490337 1 7.23
CHEMBL521793 1 6.92
CHEMBL491336 1 6.18
CHEMBL491538 1 6.18
CHEMBL491335 1 5.60
CHEMBL522283 1 4.92
CHEMBL491520 1 -
CHEMBL509274 1 -
CHEMBL526366 1 -
CHEMBL490525 1 -
CHEMBL523960 1 -
CHEMBL491521 1 -
CHEMBL491354 1 -
CHEMBL523309 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL492188 IC50 = 36.0 nM 7.44
CHEMBL491347 IC50 = 50.0 nM 7.30
CHEMBL522802 IC50 = 57.0 nM 7.24
CHEMBL490337 IC50 = 59.0 nM 7.23
CHEMBL521793 IC50 = 119.0 nM 6.92
CHEMBL491336 IC50 = 661.0 nM 6.18
CHEMBL491538 IC50 = 656.0 nM 6.18
CHEMBL491335 IC50 = 2500.0 nM 5.60
CHEMBL522283 IC50 = 12000.0 nM 4.92
CHEMBL491520 IC50 - -
CHEMBL509274 IC50 - -
CHEMBL526366 IC50 > 14000.0 nM -
CHEMBL490525 IC50 - -
CHEMBL523960 IC50 - -
CHEMBL491521 IC50 - -
CHEMBL491354 IC50 - -
CHEMBL523309 IC50 - -