Assay Detail
Binding
CHEMBL1003887
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Inhibition of MET
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.73 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459875 | — | — | 1 | 8.89 |
| CHEMBL459876 | — | — | 1 | 8.74 |
| CHEMBL509101 | — | — | 1 | 8.74 |
| CHEMBL451809 | — | — | 1 | 8.72 |
| CHEMBL503901 | — | — | 1 | 8.64 |
| CHEMBL454356 | — | — | 1 | 8.55 |
| CHEMBL454357 | — | — | 1 | 8.51 |
| CHEMBL455386 | — | — | 1 | 8.47 |
| CHEMBL508633 | — | — | 1 | 8.42 |
| CHEMBL503139 | — | — | 1 | 8.30 |
| CHEMBL453850 | — | — | 1 | 8.09 |
| CHEMBL454101 | — | — | 1 | 8.00 |
| CHEMBL453849 | — | — | 1 | 7.52 |
| CHEMBL510316 | — | — | 1 | 7.16 |
| CHEMBL508403 | — | — | 1 | 6.33 |
| CHEMBL452306 | — | — | 1 | 6.00 |
| CHEMBL508006 | — | — | 1 | 6.00 |
| CHEMBL507573 | — | — | 1 | 6.00 |
| CHEMBL451789 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459875 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL459876 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL509101 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL451809 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL503901 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL454356 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL454357 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL455386 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL508633 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL503139 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL453850 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL454101 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL453849 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL510316 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL508403 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL452306 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL508006 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL507573 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL451789 | — | IC50 | = | 1400.0 | nM | 5.85 |