Hepatocyte growth factor receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Hepatocyte growth factor receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 25 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P08581. Start with neoplasm, then reuse UniProt P08581 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P08581 as the stable protein anchor across project notes and exports.
Hepatocyte growth factor receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 25 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ALTIRATINIB, AMG-208, AMG-337, AMIVANTAMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyHepatocyte growth factor receptor
Review this target as Hepatocyte growth factor receptor, mapped to UniProt P08581. Sequence length is 1390 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hepatocyte growth factor receptor as ChEMBL target CHEMBL3717, mapped to UniProt P08581. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Hepatocyte growth factor receptor is the right protein anchor across sources, using UniProt P08581 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 25 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Hepatocyte growth factor receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08581 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hepatocyte growth factor receptor |
| UniProt Accession | P08581 |
| Component Type | Protein |
| Sequence Length | 1390 aa |
Hepatocyte growth factor receptor
Review this target as Hepatocyte growth factor receptor, mapped to UniProt P08581. Sequence length is 1390 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Hepatocyte growth factor receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ALTIRATINIB, AMG-208, AMG-337, AMIVANTAMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5184459 | 10.72 | IC50 | 0.019 | Preclinical |
| CHEMBL5174958 | 10.46 | IC50 | 0.035 | Preclinical |
| CHEMBL3668200 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL3797911 | 9.92 | IC50 | 0.12 | Preclinical |
| CHEMBL3582305 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL3188267 | 9.89 | IC50 | 0.13 | Approved |
| CHEMBL5095061 | 9.85 | IC50 | 0.14 | Clinical |
| CHEMBL1236107 | 9.72 | Kd | 0.19 | Preclinical |
| CHEMBL3674521 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL1802904 | 9.7 | IC50 | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,290 | 3,908 | 7.5 |
| cell-based format | 412 | 751 | 7.0 |
| assay format | 192 | 357 | 7.2 |
| subcellular format | 10 | 34 | 6.9 |
| mitochondrion format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 38 | 7.3 |
| assay format | 1 | 210 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 9 | 6.9 |
| assay format | 1 | 0 | — |
| cell-based format | 1 | 0 | — |