Compound Detail
CHEMBL5184459
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Basic Information
| ChEMBL ID | CHEMBL5184459 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NHZVEUDKERINQO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
466.6
MW (Da)
0.72
ALogP
11
HBA
1
HBD
112.2
PSA (Ų)
0.54
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 10.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 10.72 | 10.72 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 0.019 | nM | 10.72 | Inhibition of human recombinant c-MET in presence of ATP by HTRF assay | 33129590 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33129590 | 10.1016/j.ejmech.2020.112946 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine