Compound Detail
CHEMBL5095061
ELZOVANTINIB 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL5095061 |
| Name | ELZOVANTINIB |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | UUDPUQDMSHQSKH-NSHDSACASA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
3
Known Names
1
Indications
Molecular Properties
409.4
MW (Da)
1.86
ALogP
8
HBA
2
HBD
121.6
PSA (Ų)
0.63
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Neoplasms
Activity Summary
IC50 6 meas. best 9.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 9.92 | 9.92 | 0.1 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 9.85 | 9.85 | 0.1 | 1 |
| SNU-5 CHEMBL614934 | IC50 | 9.77 | 9.77 | 0.2 | 1 |
| MKN-45 CHEMBL614354 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 9.12 | 9.12 | 0.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 0.12 | nM | 9.92 | Inhibition of SRC (unknown origin) | 37262349 |
| Hepatocyte growth factor receptor | IC50 | = | 0.14 | nM | 9.85 | Inhibition of MET (unknown origin) | 37262349 |
| SNU-5 | IC50 | = | 0.17 | nM | 9.77 | Antiproliferative activity against human SNU-5 cells assessed as inhibition of c... | 37262349 |
| MKN-45 | IC50 | = | 0.2 | nM | 9.7 | Antiproliferative activity against human MKN-45 cells assessed as inhibition of ... | 37262349 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 0.76 | nM | 9.12 | Inhibition of CSF1R (unknown origin) | 37262349 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 0.76 | nM | 9.12 | Inhibition of CSF1R (unknown origin) | 36335744 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37262349 | 10.1021/acs.jmedchem.3c00028 | Hepatocyte growth factor receptor | 1 |
| 37262349 | 10.1021/acs.jmedchem.3c00028 | MKN-45 | 1 |
| 37262349 | 10.1021/acs.jmedchem.3c00028 | SNU-5 | 1 |
| 37262349 | 10.1021/acs.jmedchem.3c00028 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 37262349 | 10.1021/acs.jmedchem.3c00028 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 36335744 | 10.1016/j.ejmech.2022.114884 | Macrophage colony-stimulating factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine