Assay Detail
Binding
CHEMBL5356777
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Inhibition of MET (unknown origin)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.60 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3188267 | CAPMATINIB | 4.0 | 1 | 9.89 |
| CHEMBL5095061 | ELZOVANTINIB | 2.0 | 1 | 9.85 |
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 9.40 |
| CHEMBL4594400 | GUMARONTINIB | 2.0 | 1 | 9.30 |
| CHEMBL2376648 | — | — | 1 | 9.16 |
| CHEMBL5408530 | — | — | 1 | 8.96 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 8.89 |
| CHEMBL2133806 | JNJ-38877605 | 1.0 | 1 | 8.77 |
| CHEMBL460472 | — | — | 1 | 8.70 |
| CHEMBL5275126 | — | — | 1 | 8.59 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 8.41 |
| CHEMBL3545307 | MERESTINIB | 2.0 | 1 | 8.33 |
| CHEMBL5419352 | — | — | 1 | 8.26 |
| CHEMBL5428302 | — | — | 1 | 8.00 |
| CHEMBL3039525 | GOLVATINIB | 2.0 | 1 | 7.85 |
| CHEMBL3989914 | GLESATINIB | 2.0 | 1 | 7.72 |
| CHEMBL1615181 | — | — | 1 | 7.55 |
| CHEMBL3984441 | NINGETINIB | 2.0 | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3188267 | CAPMATINIB | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL5095061 | ELZOVANTINIB | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL1230609 | FORETINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4594400 | GUMARONTINIB | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2376648 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL5408530 | — | IC50 | = | 1.09 | nM | 8.96 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2133806 | JNJ-38877605 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL460472 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5275126 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3545307 | MERESTINIB | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5419352 | — | IC50 | = | 5.51 | nM | 8.26 |
| CHEMBL5428302 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3039525 | GOLVATINIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3989914 | GLESATINIB | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1615181 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3984441 | NINGETINIB | IC50 | = | 68.0 | nM | 7.17 |