Compound Detail

CHEMBL2133806

JNJ-38877605

Phase I

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Phase I

Cn1cc(-c2ccc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL2133806
Name	JNJ-38877605
Phase	Phase I
Structure Type	MOL
InChI Key	JRWCBEOAFGHNNU-UHFFFAOYSA-N

Known Names

Jnj-38877605 JNJ-38877605-AAA

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

377.4

MW (Da)

3.21

ALogP

HBA

HBD

73.8

PSA (Å²)

0.48

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Achiral

Extended Properties

Molecular Formula	C19H13F2N7
MW	377.36
Aromatic Rings	5
Heavy Atoms	28
NP-Likeness	-2.37

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Hepatocyte growth factor receptor inhibitor	INHIBITOR	Hepatocyte growth factor receptor	✓	✓

Indications

Neoplasms

Activity Summary

IC50 23 meas. best 9.02

Kd 3 meas. best 8.7

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Hepatocyte growth factor receptor CHEMBL3717	IC50	9.02	7.2979	0.9	14
Hepatocyte growth factor receptor CHEMBL3717	Kd	8.7	8.7	2.0	1
EBC-1 CHEMBL4296411	IC50	8.08	8.08	8.4	1
TPR/MET fusion protein CHEMBL3038516	IC50	8.07	8.07	8.6	1
NON-PROTEIN TARGET CHEMBL3879801	IC50	8.02	7.9267	9.5	3
BaF3 CHEMBL614524	IC50	7.75	7.75	17.6	1
MKN-45 CHEMBL614354	IC50	7.73	7.73	18.6	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma CHEMBL1770034	Kd	6.5	6.5	320.0	1
Ribosyldihydronicotinamide dehydrogenase [quinone] CHEMBL3959	Kd	6.49	6.49	323.0	1
Phosphodiesterase 3 CHEMBL2094125	IC50	5.4	5.4	4000.0	1
Unchecked CHEMBL612545	IC50	5.0	5.0	10000.0	1

Pharmacokinetic Data

Parameter	Value	Units	Species
AUC	17325.0	ng.hr.mL-1	Rattus norvegicus
CL	12.0	mL.min-1.kg-1	Homo sapiens
Cmax	6288.42	nM	Rattus norvegicus
MRT	4.9	hr	Rattus norvegicus
T1/2	2.97	hr	Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Hepatocyte growth factor receptor	IC50	=	0.95	nM	9.02	Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as su...	27061987
Hepatocyte growth factor receptor	IC50	=	1.0	nM	9.0	Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 ...	26005523
Hepatocyte growth factor receptor	IC50	=	1.7	nM	8.77	Inhibition of c-Met (unknown origin)	34655985
Hepatocyte growth factor receptor	IC50	=	1.7	nM	8.77	Inhibition of MET (unknown origin)	37262349
Hepatocyte growth factor receptor	Kd	=	2.0	nM	8.7	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase ...	29191878
Hepatocyte growth factor receptor	IC50	=	3.0	nM	8.52	LanthaScreen Assay: The kinase assay is based on the LanthaScreen technology. La...	-
Hepatocyte growth factor receptor	IC50	=	4.0	nM	8.4	Inhibition of c-Met (unknown origin)	26717201
Hepatocyte growth factor receptor	IC50	=	4.0	nM	8.4	Inhibition of c-Met (unknown origin)	35763868
Hepatocyte growth factor receptor	IC50	=	5.5	nM	8.26	Inhibition of c-Met in human EBC-1 cells assessed as reduction in cell prolifera...	27061987
EBC-1	IC50	=	8.4	nM	8.08	Antiproliferative activity against human EBC-1 cells assessed as inhibition of c...	37262349
TPR/MET fusion protein	IC50	=	8.6	nM	8.07	Inhibition of TPR-MET in mouse BAF3 cells assessed as reduction in cell prolifer...	27061987
NON-PROTEIN TARGET	IC50	=	9.5	nM	8.02	Antiproliferative activity against human EBC1 cells after 72 hrs	26005523
Hepatocyte growth factor receptor	IC50	=	9.5	nM	8.02	Inhibition of c-Met in human MKN45 cells assessed as reduction in cell prolifera...	27061987
NON-PROTEIN TARGET	IC50	=	10.9	nM	7.96	Antiproliferative activity against human MKN45 cells after 72 hrs	26005523
NON-PROTEIN TARGET	IC50	=	15.8	nM	7.8	Antiproliferative activity against human SNU5 cells after 72 hrs	26005523
BaF3	IC50	=	17.6	nM	7.75	Antiproliferative activity against mouse BAF3/TPR-Met cells after 72 hrs	26005523
MKN-45	IC50	=	18.6	nM	7.73	Antiproliferative activity against human MKN-45 cells assessed as inhibition of ...	37262349
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Kd	=	320.0	nM	6.5	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase ...	29191878
Ribosyldihydronicotinamide dehydrogenase [quinone]	Kd	=	323.0	nM	6.49	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase ...	29191878
Phosphodiesterase 3	IC50	=	4000.0	nM	5.4	Scintillation Proximity Assay (SPA): The kinase assay is based on the LanthaScre...	-

Literature References

PubMed	DOI	Target Context	# Activities
26254279	10.18632/oncotarget.4214	Hepatocyte growth factor receptor	8
27288183	10.1016/j.bmc.2016.05.057	Rattus norvegicus	6
29191878	10.1126/science.aan4368	Unchecked	5
-	10.6019/CHEMBL4495565	SARS-CoV-2	4
26005523	10.1021/ml5004876	NON-PROTEIN TARGET	3
27061987	10.1016/j.ejmech.2016.03.076	Hepatocyte growth factor receptor	3
27061987	10.1016/j.ejmech.2016.03.076	TPR/MET fusion protein	3
-	10.6019/CHEMBL4808148	Histone deacetylase 6	2
34902246	10.1021/acs.jmedchem.1c01671	NCI-H596	2
-	10.6019/CHEMBL4495564	Replicase polyprotein 1ab	2
29191878	10.1126/science.aan4368	AP2-associated protein kinase 1	1
29191878	10.1126/science.aan4368	Tyrosine-protein kinase ABL1	1
29191878	10.1126/science.aan4368	Acyl-CoA dehydrogenase family member 10	1
29191878	10.1126/science.aan4368	Acyl-CoA dehydrogenase family member 11	1
29191878	10.1126/science.aan4368	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	1
29191878	10.1126/science.aan4368	Peroxisomal acyl-coenzyme A oxidase 1	1
29191878	10.1126/science.aan4368	Peroxisomal acyl-coenzyme A oxidase 3	1
26254279	10.18632/oncotarget.4214	Unchecked	1
29191878	10.1126/science.aan4368	Actin-related protein 3	1
29191878	10.1126/science.aan4368	Activin receptor type-1	1

Data from ChEMBL 36 via Core Engine