Assay Detail
Functional
CHEMBL3583354
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Antiproliferative activity against human MKN45 cells after 72 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.47 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2133806 | JNJ-38877605 | 1.0 | 1 | 7.96 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.42 |
| CHEMBL3582294 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2133806 | JNJ-38877605 | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL3582294 | — | IC50 | = | 90.9 | nM | 7.04 |