Assay Detail
Functional
CHEMBL5356782
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Antiproliferative activity against human EBC-1 cells assessed as inhibition of cell growth
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EBC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.08 | 8.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428302 | — | — | 1 | 8.65 |
| CHEMBL4594400 | GUMARONTINIB | 2.0 | 1 | 8.30 |
| CHEMBL2133806 | JNJ-38877605 | 1.0 | 1 | 8.08 |
| CHEMBL5275126 | — | — | 1 | 7.77 |
| CHEMBL3039525 | GOLVATINIB | 2.0 | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428302 | — | IC50 | = | 2.22 | nM | 8.65 |
| CHEMBL4594400 | GUMARONTINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2133806 | JNJ-38877605 | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL5275126 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3039525 | GOLVATINIB | IC50 | = | 24.0 | nM | 7.62 |