Assay Detail
Binding
CHEMBL3801041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISA
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.63 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3797911 | — | — | 1 | 9.72 |
| CHEMBL3797579 | — | — | 1 | 9.62 |
| CHEMBL3800471 | — | — | 1 | 9.38 |
| CHEMBL3797914 | — | — | 1 | 9.34 |
| CHEMBL3799192 | — | — | 1 | 9.31 |
| CHEMBL3798905 | — | — | 1 | 9.30 |
| CHEMBL3800420 | — | — | 1 | 9.30 |
| CHEMBL3800559 | — | — | 1 | 9.23 |
| CHEMBL3799263 | — | — | 1 | 9.05 |
| CHEMBL2133806 | JNJ-38877605 | 1.0 | 1 | 9.02 |
| CHEMBL3800427 | — | — | 1 | 8.92 |
| CHEMBL3800295 | — | — | 1 | 8.92 |
| CHEMBL3797871 | — | — | 1 | 8.85 |
| CHEMBL3798623 | — | — | 1 | 8.70 |
| CHEMBL3797547 | — | — | 1 | 8.64 |
| CHEMBL3798174 | — | — | 1 | 8.64 |
| CHEMBL3797307 | — | — | 1 | 8.60 |
| CHEMBL3800061 | — | — | 1 | 8.55 |
| CHEMBL3798660 | — | — | 1 | 8.49 |
| CHEMBL3799924 | — | — | 1 | 8.39 |
| CHEMBL3798130 | — | — | 1 | 8.38 |
| CHEMBL3798590 | — | — | 1 | 8.28 |
| CHEMBL3798542 | — | — | 1 | 8.16 |
| CHEMBL3798746 | — | — | 1 | 7.98 |
| CHEMBL3798974 | — | — | 1 | 6.90 |
| CHEMBL3799231 | — | — | 1 | 6.89 |
| CHEMBL3798619 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3797911 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL3797579 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL3800471 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL3797914 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL3799192 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL3798905 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3800420 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3800559 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL3799263 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2133806 | JNJ-38877605 | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL3800427 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3800295 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3797871 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3798623 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3797547 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3798174 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3797307 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3800061 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3798660 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3799924 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3798130 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3798590 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3798542 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3798746 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL3798974 | — | IC50 | = | 126.6 | nM | 6.90 |
| CHEMBL3799231 | — | IC50 | = | 129.2 | nM | 6.89 |
| CHEMBL3798619 | — | IC50 | = | 413.2 | nM | 6.38 |